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Peptides and proteins were identified with a 1% false discovery rate (FDR) (Tang et al., LC-MS/MS Analysis in MRM Mode LC-MRM experiments were performed on an identical LC platform and column, and a QTRAP 5500 (Sciex, Concord, ON) hybrid quadrupole-linear ion trap system with a TurboIonSpray ion source in positive mode

3D brain organoids derived from human pluripotent stem cells (hPSCs), including embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), replicate the cytoarchitectural complexity of the human brain and offer unprecedented opportunities to investigate disease pathogenesis

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