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Teleanu DM, Niculescu AG, Lungu II, Radu CI, Vladcenco O, Roza E, MDPI et al (2022) An overview of oxidative stress, neuroinflammation and neurodegenerative diseases

IGF-1 has specific and stimulatory effects on granulosa cells, and it was reported to increase the expression of steroidogenic enzymes CYP11A1, 3-hroxysteroid dehydrogenase (3HSD), CYP19A1, along with IGF-1R, and FSHR gene expression (70)

Women with PCOS tend to have lower plasma selenium concentrations, potentially contributing to free radical accumulation and hyperandrogenism

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doi:10.2147/ccid.S201290