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Compared to mice with normal Gls1 expression, Gls1-deficient mice exhibited a significant increase in overall survival after radiotherapy, and their levels of natural killer cells and interferon alpha/gamma proteins were significantly higher than those of mice with normal Gls1 expression

Samra B, Kantarjian H, Sasaki K, Short N, Khouri R, Khoury J, Champlin R, Kebriaei P, Cortes JE, Jorgensen J, Wang SA, Garcia-Manero G, Kadia T, Borthakur G , Verstovsek S, Daver N, Montalban-Bravo G, Jain N, Konopleva M, Yilmaz M, Naqvi K, O'Brien S, Ravandi F, Jabbour E

In addition, in vitro assays in mouse macrophages revealed a significant increase in succinic acid expression upon glycolytic activation

PMID: 7952484