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We order vitamin B12 and folate testing when a person with Down syndrome we are evaluating has symptoms described above, has a lab abnormality for which follow up testing of vitamin B12 and/or folate is indicated, or the person has a condition in which deficiency is common (e.g., celiac disease)

This typically follows confirmed diagnosis of B12 deficiency through blood tests and clinical assessment

Clinical Nutrition Open Science, 41, 100065

The people most commonly recommended for B12 injections therapy include those who: Are aging Cannot metabolize food properly Do not eat animal products, i.e

B12 is also necessary for proper red blood cell (RBC) formation, neurological and brain function and protein and fat metabolism