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These include senolytics, which aim to block the transition of cells into a senescent state, and senoreversers, which promote the exit of senescent cells from this state [99]

Thus, the strongest inhibitory effect of Epitalon on carcinogenesis in the colon mucosa was manifested when the treatment was continued throughout the experiment

However, when the investigational drug presents a higher level of risk for example in certain oncology settings, where the compound may be too toxic for healthy subjects the study may involve patients instead

HGF phosphorylates MET, ERK, and AKT (Shin et al., 2017