When bound to the lysosome surface, active ARL8-GTP directly or indirectly via association with the adaptor protein PLEKHM2/ SKIP recruits kinesins KIF1A 19,20 , and KIF5A-C 10 to promote microtubule-dependent lysosome dispersal to the cell periphery
The study population was comprised of 281 participants: 160 in the exposed and 121 in the non-exposed group
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When the liver is overloaded or glutathione levels are low, it can disrupt sleep, often causing you to wake up between 2:00 AM and 4:00 AM, sometimes with night sweats or a dull headache