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PMID 28108470

Zecchini et al

Regarding exogenous glutathione intake, scientific studies indicate that this is distinct from endogenous synthesis and may not substitute or replicate the protective metabolic roles fully

Since the energy requirements for glutamate uptake are extremely high, the reversal of glutamate transport is preceded by a decline in astrocytic glutamate uptake, which signifies the earliest astrocytic contribution to the development of glutamate excitotoxicity, together with the already reversed glutamate uptake in neurons (Rossi et al., 2000)