Klotho has pleiotropic renal protective actions, including anti-fibrosis, anti-oxidative stress, anti-inflammation, anti-apoptosis (Yuan et al., 2022), and modulation of autophagy ( Klotho is strongly expressed in the kidney and the level there is related to its functional state (Wang et al., 2018
Human Growth Hormone (HGH) is used to treat HGH deficiency and occasionally to improve oocyte quality in patients with severe diminished ovarian reserve
However, after treatment, a significant reduction in scores was observed only in the patients treated with Esoxx Defence
Os GLP-1s passaram por extensos testes humanos e so aprovados, por exemplo, pelo organismo regulador de medicamentos do Reino Unido (a MHRA)
However, this was not a controlled trial there was no placebo group, and the assessments were informal (patient surveys by phone)