Other (less serious) concerns are if EGF can properly penetrate the skin (as it is a medium-sized, polar molecule, so a special delivery system is probably needed), if it can affect collagen synthesis (or just works on the surface plumping up only the upmost layers of the skin) and if it has beneficial effects at all when used in isolation versus when used in a "conditioned media" that contains lots of growth factors resembling the synergistic balance found in the skin
John Wiley & Sons, Chichester, pp 193221 Fazio T, Warner CR (1990) A review of sulphites in foods: analytical methodology and reported findings
Activation of Nrf2-regulated glutathione pathway genes by ischemic preconditioning
744,745,746 Interestingly, the epigenetic changes can be reversed during regeneration, 747 highlighting the dynamic interplay between cellular proliferation and age-related epigenetic modifications
The eluted protein sample was dialysed into 50 mM Tris pH 7.4 using a 10 kDa cut-off cassette
