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Passive diffusion also occurs throughout the intestinal tract, allowing approximately 1% of oral doses to be absorbed without intrinsic factor

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A major benefit of MOTS-c is that it affects muscle tissue directly, making it the most effective treatment for insulin resistance

For in vitro analysis, differentiated human SGBS adipocytes were subjected to GPR146 knockdown using siRNA (ThermoFisher) or overexpression via doxycycline-inducible lenti-viral vectors expressing either GPP (control) or GPR146

doi: 10.3238/arztebl.2020.0701