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16 Improving nutrition by reducing carbohydrates and adhering to a Mediterranean diet high in Omega-3 fatty acids and other vital nutrients have been clearly associated with improved mental health

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The constellation of SNS overactivity, parasympathetic withdrawal, glucocorticoid receptor insufficiency, and elevated inflammatory signaling may help account, at least in part, for the increased risk of metabolic syndrome, endocrine disorders, and vascular disease seen in bipolar patients (168, 177)