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These localized microbial and metabolic alterations induce inflammatory responses within the ruminal mucosa, the systemic consequences of which will be further addressed in the inter-organ axes section 53,54
The mediating effects were 0.005 (IgD + CD24 + B cell %B cell), 0.003 (activated & resting CD4 regulatory T cell absolute count), 0.003 (CD3 on terminally differentiated CD8 + T cell), and 0.006 (HLA DR on myeloid dendritic cell), respectively
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They can have both positive and negative effects, depending on their levels and balance within the body
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