Strategic Approaches to Improvise Peptide Drugs as Next Generation Therapeutics
Preparat w formie liposomalnej jest zdecydowanie lepiej przyswajalny dla mnie ni forma kapsukowa
Huge thank you to Maria Rudis & Megan Musselman, PharmD, BCPS, BCCCP, BCEMP, FCCP, FASHP for authoring this first article (and working on a tight timeline!)
They added GHK-Cu in concentrations of 10 M to 10 M and measured: Collagen synthesis (by radioactive proline incorporation) Non-collagen protein synthesis Cell proliferation What they found: Stimulation of collagen synthesis by 70 % at the optimal concentration of 10 M (1 nM) The effect was NOT dependent on increased proliferation, fibroblasts increased production per cell Background: GHK without copper had a dramatically weaker effect , Cu is critical Reversibility: After removing GHK-Cu, synthesis returned to baseline Why it matters: This is the fundamental mechanistic study that documented the effect of GHK-Cu on collagen
The standard 4-6 weeks on, 2-4 weeks off pattern provides a structured approach even without specific data guiding these intervals
