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Additionally, certain variants in genes related to antioxidant response, such as the catalase (CAT) gene and the glutathione peroxidase (GPX) gene, have been associated with increased susceptibility to vitiligo.67,69,70 Furthermore, vitiligo has been associated with defective recycling of tetrahydrobiopterin (6BH4), essential for melanin formation, leading to an excess of 7BH4 and inhibition of phenylalanine hydroxylase (PAH)
Thus, accurate therapy is still a critical issue that needs to be resolved
While meiotic progression was always lowest in animals that received chemotherapy alone, this was not statistically significant, and we cannot conclude that chemotherapy impacts oocyte maturation