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Researchers studying NAD+ biology or methyl-donor pools should evaluate primary sources directly and note that NNMT inhibition has distinct mechanistic implications compared to direct NAD+ precursor supplementation with molecules like NMN or NAD+ itself

The Institute of Medicine reports that no adverse effects have been associated with excess vitamin B12 intake from food, supplements, or injections in healthy individuals. Nevertheless, its crucial to consult a professional before beginning any high-dosage supplement

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