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In transdermal experiments, the cumulative permeability of [Arg][Dec] vesicles was 1665.59 gcm 2 , significantly higher than the 663.8 gcm 2 reported in the literature ( 2 , with a deposition of 18.5 g/cm 2 , whereas the cumulative transdermal flux of SIN in an ethanol-water solution was only 329.2 g/cm 2 with a deposition of 5.2 g/cm 2 , indicating that SE significantly improved SINs transdermal performance