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When gut inflammation disrupts tryptophan metabolism, shunting it toward the kynurenine pathway instead of serotonin synthesis, the brain experiences a serotonin deficit even when dietary tryptophan intake is adequate

References Huang, T., Zhang, K., Sun, L., Xue, X., Zhang, C., Shu, Z., Mu, N., Gu, J., Zhang, W., Wang, Y., Zhang, Y., & Zhang, W

Though doses of up to 2,000 mcg of vitamin B12 are considered safe, its best to speak with a doctor to find out whether taking a supplement is necessary

J Phys Chem 92, 2189-96, 1988)