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Taken together, our work demonstrated that ACE induces ferroptosis in tumor cells through a dual mechanism: on the one hand, ACE enhances intracellular Fe 2+ -induced ferroptosis by directly binding and degrading PCBP 1/2, and on the other hand, ACE induces GPX4 ubiquitination and degradation by directly binding to GPX4

To mitigate population stratification, only European ancestry individuals were included

One way to decrease acetaldehyde toxicity is by increasing glutathione, your bodys master antioxidant

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