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November 2025: Phase 2 publication Later in 2025, a 48-week Phase 2 trial reported dose-dependent weight loss, including about 20.1% at the highest fixed dose

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Ursolic acid attenuates cholestasis through NRF2-mediated regulation of UGT2B7 and BSEP/MRP2

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Beyond effects on inflammatory cells, GLP-1RAs also suppress group 2 innate lymphoid cells (ILC2) activity, significantly reducing their production of IL-5 and IL-13, cytokines critical for eosinophil survival and goblet cell metaplasia [65]