Understanding the comparison between cigarette smoking and vaping is essential, especially for individuals aiming to use vaping as a tool to reduce or quit smoking altogether
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1 The safety profile of combination NRT is comparable to monotherapy 7,8 and even with combination NRT, the levels of nicotine received are unlikely to be higher than those received from smoking 9 The efficacy of combination NRT for smokers who want to quit is recognised by NICE and the National Centre for Smoking Cessation and Training (NCSCT): 3,9 There is good evidence to show that combination NRT is more effective than single product use. NCSCT 9 NRT has been shown to be an effective pharmacotherapy 2 It provides a temporary substitute for the nicotine that smokers receive from cigarettes and delivers nicotine without the other harmful toxins that are found in tobacco 2,3 The use of NRT aims to assist smokers who want to quit by helping to relieve the urge to smoke along with nicotine withdrawal symptoms, such as irritability, low mood and restlessness 2,4 Absorption of nicotine from NRT is either mucosal (oral and nasal formats) or transdermal (patch) 5 While transferred nicotine dependence from cigarettes to NRT is rare, it is both less harmful and easier to break than smoking dependence 3,6 In a Cochrane review, NRT was found to increase quit rates by 55% compared with the use of placebo or no NRT
Immunoblotting analyses Immunoblotting analyses of the rat trachea lysates were performed to confirm that antibodies that demonstrated smoke-induced changes with the antibody microarray were in fact specific for their intended target proteins
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