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The Kuzminski trial involved 33 patients (18 in the oral arm and 15 in the intramuscular arm), while the Bolaman trial involved 60 (26 in the oral arm and 15 in the intramuscular arm)

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By inhibiting NNMT activity, 5-Amino-1MQ modulates enzymatic processes associated with nicotinamide metabolism, methylation network regulation, and intracellular cofactor-associated signaling systems