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Non-Classical Pathways Unlike full-length hGH, which exerts its lipolytic effects through the classical GH receptor and JAK-STAT signaling, AOD-9604 operates through alternative, receptor-independent pathways

HRMC cells were cultivated in HG conditions, and HU effectively attenuated the HG-induced inflammation and apoptosis

doi: 10.1210/jc.2003-031802 13 GeserickCMeyerH-AHaendlerB

Sample sizes were small and the study has never been replicated at scale, so take it as suggestive, not definitive

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