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In fact, even healthy people can only tolerate a certain amount of histamine

Justenhoven, Christina

For example, glutathione is a ROS scavenger and its concentration was observed to be reduced both in experimental models (Chen et al., 1989

1m), indicating that KG-induced therapeutic resistance is not simply due to a CCNE1- or MYC-driven replication stress response

Other synaptic signalling molecules positively associated with cognitive fitness in AD include neuritin-1 (NRN1) 11,12,13,16 and brain-derived neurotrophic factor (BDNF) 17,18 , whereas proteins associated with cognitive frailty include gut-derived cholecystokinin (CCK) and the chromogranins A/B (CHGA/B) 11,19