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Shen X, Li H, Zhang B et al (2025) Tau-targeted therapeutic strategies: mechanistic targets, clinical pipelines, and analysis of failures

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collagen synthesis pathways

This review aims to provide some mechanistic insights into how a shift in specific populations of microbes and their derived metabolites in the gut triggers and facilitates various disease processes, including chronic intestinal and systemic inflammation, protein misfolding and aggregation, dysfunctional protein clearance, and a heightened autoimmune response, thereby contributing to disease propagation in the brain

6) and may be progenitors of new chemical classes of radioprotectant drugs