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The critical link between climate change and health is one of the most pressing challenges for planners, as extreme heat is a major driver of rising mortality rates and has become the most frequent natural disaster

The trial endpoints include both traditional AD outcomes (e.g., cognition, brain imaging, AD fluid biomarkers) and gold standard aging measures (e.g., frailty, physical function, epigenetic age, etc.)

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IUSCT is a non-myeloablative, non-immunosuppressive alternative conferring various unique advantages and may also offer safer postnatal management