Wherein CP interacts with the accessible Met-rich motifs to form the [Pt(Met)Cl(NH 3 ) 2 ] intermediate, which induces a conformational change in Ctr1 and allows CP to pass laterally through the axis of the trimeric Ctr1 channel and move inward via the intermolecular sulfursulfur process exchange ( In addition, OCTs (e.g., OCT1 and OCT2), as the active transport proteins, mediate the endocytosis and efflux of organic cations driven by intramembrane negative potentials
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