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6-monthly safety reports on the safety of subjects in all clinical trials of the investigational medicinal product (IMP) for which the sponsor is responsible worldwide, with a global line listing of SUSARs occurring in these trials in the reporting period

[DOI] [PMC free article] [PubMed] [Google Scholar] 199.Silveira ACA, de Oliveira RC, Rodrigues CC, Teixeira SC, Borges BC, da Silva CV

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Second, intracerebroventricular infusion of a non-selective MCR agonist, melatonin-II, reduces voluntary ethanol drinking in adult alko alcohol (AA) rats (Ploj et al., 2002) and C57BL/6J mice (Navarro et al., 2003), while the administration of AgRP increases alcohol consumption (Navarro et al., 2003)