Repletion of vitamin B12 may improve response in patients resistant to antidepressants (10) , and in older adults with major depression, long-term supplementation with a combination of B12, B6, and folic acid enhanced antidepressant treatment efficacy (40)
But here is where things get complicated
At first, you might need shots more frequently, perhaps every day for a couple of weeks, until your symptoms start to improve
Specifications 50 H 69 N 15 O 9 Reconstitution For diluting lyophilized peptide powders, use a sterile and suitable research solvent such as bacteriostatic water (BAC), which may help support handling stability and reduce contamination risk
Basdevant, Nutritional deficiency after gastric bypass: diagnosis, prevention and treatment, Diabetes & Metabolism, Volume 33, Issue 1, February 2007, Pages 13-24, ISSN 1262-3636, Eussen SM, de Groot LM, Clarke R, et al