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Practical Implications As a practical matter, these changes to the interim list are of limited immediate consequence

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In particular, LEAP2 (liver-expressed antimicrobial peptide 2), an endogenous antagonist of the ghrelin receptor GHSR, has emerged as a potential target for mitigating the weight regain often observed after discontinuation of GLP-1-based therapies [22,23]

Same peptide sequence

This dual mechanism explains why the compound produces such pronounced effects on adipose tissue lipid content without affecting lean tissue or overall energy intake in research models