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Following the identification of initial cases in Wuhan, China, in December 2019, the severe acute respiratory syndrome coronavirus 2 has continued to spread worldwide, with COVID-19 declared a pandemic on 11 March 2020 [163,164,165]

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Additionally, Mg, Zn, and Cu are crucial cofactors for the activity of antioxidant enzymes, including SOD 32

The decrease in cAMP in vascular smooth muscle cells was correlated with an increase in the production of the superoxide anion [41]