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[169] In the 18th century smoking became far more sparse in painting as the elegant practice of taking snuff became popular

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Given that different rates of product switching were expected in the two study arms (with a higher rate in the NRT arm), the exclusion of all participants who used non-allocated products would be likely to result in an overestimation of the cessation rate in the arm allocated to the less effective treatment and an underestimation of the difference between groups