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Research suggests it acts through modulation of several interconnected signaling pathways simultaneously a broad mechanism of action that helps explain its observed multisystemic effects in laboratory models, and that also makes it challenging to evaluate through conventional single-target drug development frameworks

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A straight laser Doppler probe (outer diameter: 0.9 mm) was directed to the papilla between the two upper incisal teeth using manipulator fixation

doi:10.1111/j.1365-2133.2009.09216.x