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A 50% toxicity rate was reached at 0.94mmol/l in HepG2 and 0.68mmol/l in HepG2 ATP7B-KO cells

The duration of the treatment and RPM doses are summarized in Table 4

It has been efficient in increasing the TDDs with varying molecular weights including small (fentanyl, orcalcein) to high molecular weight drugs weighing up to 40 kDa

By enabling the cells to burn fat for fuel rather than relying exclusively on anaerobic glycolysis, L-carnitine helps prevent the rapid, toxic accumulation of lactic acid in skeletal muscle tissue

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