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The two isoforms are encoded by different genes

[DOI] [PMC free article] [PubMed] [Google Scholar] 84.Wibrand K., Berge K., Messaoudi M., Duffaud A., Panja D., Bramham C.R., Burri L

Temporal course of plasma trimethylamine n-oxide (TMAO) levels in ST-elevation myocardial infarction

24 With respect to this, the negative association between frequency of the cSHMT -C1420T variant and latitude documented in this study may indicate that activity of the de novo thymidylate synthesis pathway is increasingly impaired in populations exposed to higher UVR, but the burden of this variant is unclear due to mSHMT likely maintaining cSHMT activity in such cases

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