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As with any supplement, it's best to consult a doctor to ensure the ingredient is safe for you to take

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Administration in Special Populations 7.1 Administration to Elderly Patients In older adults, age-related physiological changes may influence glutathione metabolism and clearance

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NNMT (nicotinamide N-methyltransferase) is an enzyme that methylates nicotinamide, diverting it from NAD+ synthesis