Ishizawa J, Nakamaru K, Seki T, Tazaki K, Kojima K, Chachad D, DiNardo CD, Pierce S, patel KP, Tse A, Davis RE, Rao A, Andreeff M
Bareggi SR, Cornelli U (2012) Clioquinol: review of its mechanisms of action and clinical uses in neurodegenerative disorders
Supplementation with riboflavin can act as a molecular chaperone, restoring structure and improving function in FAD-domain mutants (71)
The identification of this protein sparked interest among researchers, who began to explore its potential therapeutic applications beyond the gastrointestinal system
Thus, since several mutations affecting the functional domains of p62 have been identified in patients with ALS and frontotemporal dementia, it has been demonstrated that p62 variants exhibit reduced KEAP1-binding, preventing NRF2 from entering the nucleus and promoting protective genes, and predisposing the cell death upon exposure to ROS [250, 251]