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Massart R, Mongeau R, Lanfumey L

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As of yet, 300 distinct mutations have been pinpointed on this gene

CPP-CAND disrupts FOXO4-p53 foci and induces apoptosis through caspase-dependent pathways FOXO4 is progressively recruited to euchromatin foci following senescence induction and is retained in the nucleus of senescent cells through its interaction with p53, contributing to the maintenance of the senescent state 34

Notably, the corresponding mechanistic relationships remain to be elucidated