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For instance, selectively blocking lactylation-driven inflammatory programs in microglia while preserving neuronal lactate oxidation could pave the way for precision neurometabolic therapies

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Critically, mast cells and microglia communicate and co-activate in response to environmental stimuli

This is particularly relevant in muscle and cardiovascular research models

These results suggest that many of the beneficial effects of CR on memory, especially in males, may result from reduced tau pathology or altered molecular signaling, and not from the reduction in plaques