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In addition, those who have COMT Val/Val genotype (genotype with greater enzyme expression) were associated with a significantly increased risk of UF as compared to those with Val/Met genotype (intermediate expression) and Met/Met genotype (low expression), which could have explained the higher risk of UF in African American women (47% having Val/Val genotype) ( In vitro study showed that the ability of green tea extract in inhibiting the proliferation of leiomyoma cells is in part due to the potential of EGCG in reducing the expression of the COMT enzyme (Zhang et al., 2014)

Dr Bonning said the TGA needed to be given "more powers to act and be proactive in addressing this risk"

doi: 10.1186/1423-0127-17-s1-s23 25

A 2016 study found that B12 supplements that are mixed with saliva are broken down and absorbed better than supplements that are swallowed whole like capsules or soft gels

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