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L-arginine enhances nitric oxide synthesis and improves blood flow, further supporting the peptides role in pain management

Neishaboori N, Wadhwa R, Nogueras-Gonzalez GM, Elimova E, Shiozaki H, Sudo K, Charalampakis N, Hiremath A, Lee JH, Bhutani MS, Weston B, Blum MA, Rogers JE, Garris JL, Rice DC, Komaki R, Swisher SG , Skinner HD, Hofstetter WL, Ajani JA

It contains a substitution of arginine for glutamic acid at position 3 and an N-terminal extension of 13 amino acids

Treatment of metastatic colorectal cancer: ASCO guideline

Additionally, it inhibits fatty acid synthase expression by activating the AMPK pathway, thus inhibiting fatty acid synthesis [188, 189]