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Author Contribution Statement The manuscript has been read and approved by all the authors and each author believes that the manuscript represents honest work

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Consistent with the approach adopted in the FY 2022 IPPS/LTCH PPS final rule, if a hospital would be trimmed under both the UCC trim methodology and this alternative trim, we will apply this trim in place of the existing UCC trim methodology

Dectin-1, a key component of the host defense mechanism, is a C-type lectin receptor that can recognize cell wall-associated -1,3-glucan

Use of food and supplements to regulate testosterone levels may be a promising therapeutic alternative to testosterone replacement therapy