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New risk biomarkers are needed to improve early risk stratification, including inflammatory mediators, oxidative stress markers, lipidomic and metabolomic profiles, and indicators of gut barrier integrity

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The kits were purchased from Nanjing Jianjian Bioengineering Institute, and the methods for the determination of total cholesterol (TC), total bile acids (TBA), high-density lipoproteins (HDL), low-density lipoproteins (LDL), and triglycerides (TG) were in accordance with the instructions