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The metabolome regulates the epigenetic landscape during naive-to-primed human embryonic stem cell transition

doi: 10.1183/23120541.00494-2021 115 ChalmersJDHaworthCSMeterskyMLLoebingerMRBlasiFSibilaOet al

There's no controlled research establishing that dose or frequency changes the likelihood of this reported effect, but the most consistently recommended practical step across community discussion is starting at a reduced frequency, two to three times a week rather than daily, for the first couple of weeks, then building up gradually

Visible body composition changes typically emerge around week 3-4, with significant fat loss and waist circumference reduction becoming apparent by weeks 5-8

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