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A deficiency can also cause issues such as diarrhea, nausea, vomiting, lack of appetite, weight loss, pale skin, numbness and tingling in your hands and feet, confusion, irritability, depression, and behavior changes

Only 4.2% of participants discontinued due to side effects after week 24, indicating that side effects become manageable or resolve entirely for the vast majority who continue treatment

A review of vitamin B12 in dermatology

Tanner JM, Hughes PC, Whitehouse RH

Peripheral inflammatory mediators may also activate the vagus nerve to transmit signals to the central nervous system (Capuron and Miller, 2011)