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A visible sign of protein denaturation that reduces bioavailability by 1525% according to stability studies in Pharmaceutical Research

doi: 10.1159/000217965 34 VoigtAZintlF

These headaches are typically transient, lasting a few hours, and respond to standard over-the-counter pain relief

Yet the consequences are unknown Bioavailability: there are four specific metabolic steps necessary to convert cyanocobalamin into one of the coenzyme forms, which is a clear metabolic disadvantage (3) Utilisation problems: certain hereditary diseases, as well as metabolic disorders, prevent the conversion of cyanocoalamin into the active B12 forms (4) Steals methyl groups: cyanocobalamin requires a methyl group to convert into methylcobalamin, which it takes from the important amino acid S-adenosylmethionine (SAM)

PMID 19255021