Research has suggests that nicotine produces rewarding effects not through a single neurotransmitter system, but through the integrated actions of dopaminergic, GABAergic, glutamatergic systems and atypical rewarding pathways, which together facilitate spatiotemporally specific neuroplastic adaptations (Wooltorton et al., 2003
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A randomized, double-blind, placebo-controlled study of histone deacetylase type 6 inhibition for the treatment of painful diabetic peripheral neuropathy
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