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Covalent bonding of heme to protein prevents heme capture by nontypeable Haemophilus influenzae

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This is due to its basis on Michaelis-menten and first order kinetics which are closely associated with the catalytic reaction mechanism of enzymes (Boeckx et al., 2017)

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Due to the increased amount of adipose tissue, obese patients are more predisposed to systemic inflammation with higher levels of pro-inflammatory cytokines, such as interleukin 6, eotaxin-1, TNF-, transforming growth factor beta 1 (TGF-1) and CRP