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Abbreviations Kla: Lysine lactylation LDH: Lactate dehydrogenase MCTs: Monocarboxylate transporters PTMs: Post-translational modifications HIF-1: Hypoxia-inducible factor 1-alpha TAMs: Tumor-associated macrophages EMT: Epithelial-mesenchymal transition TME: The tumor microenvironment CAFs: Cancer-associated fibroblasts ICIs: Immune checkpoint inhibitors ACSS2: Acetyl-CoA synthetase 2 GNAT: GCN5-related N-acetyltransferase CBP: CREB-binding protein AARS1: Alanyl-tRNA synthetase 1 TEAD1: TEA-domain-transcription-factor-1 cGAS: Cyclic-GMP-AMP synthase H3K18la: H3 lysine-18 lactylation sEVs: Small extracellular vesicles CCSCs: Colorectal cancer stem cells GSCs: Glioma stem cells ECM: Extracellular matrix EC: Esophageal cancer ESCC: Esophageal squamous cell carcinoma GC: Gastric cancer CRC: Colorectal cancer HCC: Hepatocellular carcinoma PC: Pancreatic cancer PDAC: Pancreatic ductal adenocarcinoma NSCLC: Nonsmall cell lung cancer MM: Multiple myeloma RCC: Renal cell carcinoma References Zhang D, Tang Z, Huang H, Zhou G, Cui C, Weng Y, et al
The physiological, biochemical, and molecular roles of zinc transporters in zinc homeostasis and metabolism
Sperm need this energy to swim effectively and reach the egg
Caprylic acid destroys candidas protective cellular membrane (called a biofilm)
10.1016/j.jmb.2014.08.023 J
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