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CONCLUSION Antioxidants are under active investigation in the treatment of male infertility

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Mammen Mammen et al., 2019)

Metabolic Consequences of Folate Insufficiency The effects of folate deficiency on the methionine cycle have widespread metabolic consequences, including: Altered DNA Methylation Patterns Insufficient folate reduces the availability of methyl groups for DNA methylation, leading to epigenetic instability

This view is consistent with arterio-venous difference studies showing that the brain is a net exporter of free choline, with the rate of choline efflux varying depending on metabolic conditions [70, 79]