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Its mechanisms include: Nitric oxide modulation regulates blood flow and inflammation at injury sites Growth factor upregulation increases EGF, FGF, and VEGF expression Gut-brain axis signaling systemic effects mediated through the GI tract Dopaminergic system interaction neuroprotective properties BPC-157 is unique among healing peptides because it works systemically through the gut , even when administered locally

10.15420/ecr.2018.33.1 60 WuC.-C.LuK.-C.LinG.-J.HsiehH.-Y.ChuP.LinS.-H.et al (2012)

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A direct comparative analysis elucidates how these agents may be positioned rationally as adjunctive or alternative interventions depending on clinical phenotype, biological vulnerability, and therapeutic goals